DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals

J Lazarus; KA Mather; NJ Armstrong; F Song; A Poljak; A Thalamuthu; T Lee; NA Kochan; H Brodaty; MJ Wright; D Ames; PS Sachdev; JBJ Kwok

Journal article

DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals

J Lazarus, KA Mather, NJ Armstrong, F Song, A Poljak, A Thalamuthu, T Lee, NA Kochan, H Brodaty, MJ Wright, D Ames, PS Sachdev, JBJ Kwok

Journal of Alzheimer S Disease | IOS PRESS | Published : 2015

DOI: 10.3233/JAD-141314

Abstract

Background: DNA methylation variation has been implicated in memory, cognitive performance, and dementia. Plasma apolipoprotein-A1 (ApoA1) levels may act as a biomarker of age-associated cognitive performance and decline. Objectives: To estimate the heritability of plasma ApoA1 protein levels; to examine DNA methylation variation within the APOA1 gene; and to investigate whether APOA1 methylation is associated with plasma ApoA1 levels and episodic memory performance. Method: Heritability of ApoA1 protein levels in Older Australian Twins Study (OATS) was assessed using structural equation modelling. APOA1 methylation levels were assayed in two cohorts of cognitively normal older individuals. ..

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University of Melbourne Researchers

David Ames Author

Related Projects (2)

THE OLDER AUSTRALIAN TWINS STUDY (OATS) OF HEALTHY BRAIN AGEING AND AGE-RELATED NEUROCOGNITIVE DISORDERS

Ageing is associated with cognitive decline and dementia. It is still not completely understood what relative contributions genes and enviro..

GENE-ENVIRONMENT INTERACTION IN HEALTHY BRAIN AGEING AND AGE RELATED NEURODEGENERATION

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Grants

Funding Acknowledgements

We would like to acknowledge and thank the OATS and Sydney MAS participants, their supporters and respective Research Teams. OATS is supported by the National Health and Medical Research Council (NHMRC)/Australian Research Council Strategic Award 401162, the NHMRC Project Grant 1045325 and was facilitated via access to the Australian Twin Registry, a national research resource, which is administered by the University of Melbourne and supported by the NHMRC Enabling Grant 310667. Sydney MAS was supported by the Australian National Health and Medical Research Council (NHMRC) Program Grants 350833 and 568969. This work was also facilitated by the Australian Research Council Discovery Project Grant DP120102078 and the Rebecca L. Cooper Medical Research Foundation. DNA was extracted by Genetic Repositories Australia, an Enabling Facility supported by the NHMRC Grant 401184. John Kwok was supported byNHMRCgrant APP1021269. Jessica Lazarus was supported by the Cowled Postgraduate Scholarship in Brain Research. Henry Brodaty is supported by the AustralianGovernment funded Dementia Collaborative Research Centre (DCRC), University of NewSouthWales. Nicola Armstrongwas supported by the NHMRC Project Grant 525453 and Karen Mather is supported by an Alzheimer's Australia Dementia Research Foundation Postdoctoral Fellowship and the NHMRC Capacity Building Grant 568940.